- the clean living, health concious over-indulger
relieving the symptoms associated with the over-indulgence of drink
what is silymarin?
- silymarin is the active compound in milk thistle which is extracted from the seed of the plant.
- "silymarin stimulates detoxification pathways and stimulates the regeneration of liver tissue" US NIR National Cancer Institute, Complemetary Therapies Editorial Board 2003
- alcohol is one of the best known toxins that damages the liver and large amounts creates extreme oxidative stress on liver tissue. Significant alcohol consumption produces accumulations of fat in liver cells, with small areas of dead tissue, accompanied by a rise in liver enzymes in the blood (from leaking, dying cells).
- in a study with healthy volunteers receiving single doses of either one (175mg), two (350mg) or 3 (475mg) of milk thistle capsules  it was found that biomarkers for oxidative stress were decreased in volunteers after 28 days. And, this effect was dose proportional .
- silymarin is also thought to protect the brain due to the role it plays in protecting cells from oxidative stress. In the brain oxidative stress is caused by by-products of reactions involving oxygen and the breakdown of ethanol within the cell metabolism 
- a study by Ferenci et al. demonstrated this in a placebo controlled trial of the use of silymarin in people with cirrhosis. A systematic review published in 2005 by Rambaldi et al. studied 13 randomised control trials and concluded that silymarin may increase the life expectancy of patients with liver disease 
- lightweight, convenient eco-friendly foil packaging. Travel bag, wash bag, work bag friendly
|Study||Disease||Silymarin Dosage (mg/day)||Treatment Duration (days)||Results|
|Ferenci ||Chronic alcohol and other forms of liver disease||420||730||58% of patients increased life expectancy|
|Salmi ||Chronic alcohol liver disease||420||28||73% of patients improved|
|Palasciano ||Chronic drug-induced liver disease||800||90||Reduction in liver cell damage|
|Buzelli ||Chronic hepatitis||240||7||Reduction in liver cell damage
 Zhu, H.-J., et al., An Assessment of Pharmacokinetics and Antioxidant Activity of Free Silymarin Flavonolignans in Healthy Volunteers: A Dose Escalation Study. Drug Metabolism and Disposition, 2013. 41(9): p. 1679-1685.  Coyle, J.T. and P. Puttfarcken, Oxidative stress, glutamate, and neurodegenerative disorders. Science, 1993. 262(5134): p. 689-695.  Ferenci, P., et al., Randomized controlled trial of silymarin treatment in patients with cirrhosis of the liver. Journal of Hepatology, 1989. 9(1): p. 105-113.  Rambaldi, A., B.P. Jacobs, and C. Gluud, Milk thistle for alcoholic and/or hepatitis B or C virus liver diseases. Cochrane Database Syst Rev, 2007(4): p. Cd003620.  Salmi, H.A. and S. Sarna, Effect of Silymarin on Chemical, Functional, and Morphological Alterations of the Liver. Scandinavian Journal of Gastroenterology, 1982. 17(4): p. 517-521.  Palasciano, G., et al., The effect of silymarin on plasma levels of malon-dialdehyde in patients receiving long-term treatment with psychotropic drugs. Current Therapeutic Research, 1994. 55(5): p. 537-545.  Buzzelli, G., et al., A pilot study on the liver protective effect of silybin-phosphatidylcholine complex (IdB1016) in chronic active hepatitis. Int J Clin Pharmacol Ther Toxicol, 1993. 31(9): p. 456-60.
- take 1 tablet before you start drinking and 1 before bed.
- 400 mg of silymarin in each tablet
- 20 tablet pouch
- maximum 2 tablets per day
- milk thistle seed extract
- 400 mg of silymarin in each tablet
- tableting agent: microcrystalline cellulose
- anti-caking agents: silicon dioxid & magnesium stearate
- silymarin is a compound found in milk thistle
- our 400mg strength tablets may be beneficial to people looking to relieve the symptoms associated with the occasional over-indulgence in drink
- take 1 tablet before you start drinking and 1 before bed
What is milk thistle and how does it work?
SIlymarin - the compound found in milk thistle "stimulates detoxification pathways & the regeneration of liver tissue" *. Can this become your hangover cure?
Ever wondered what alcohol does to your brain?
Alcohol can often lead to a somewhat drastic loss of inhibitions, causing some drinkers to be a little emotional, overindulgent, and uncharacteristically adventurous while under the influence.
What is a hangover? The biological effects of your night out
Ever wondered why over-indulging in alcohol has to be so consequently painful the next morning? Most studies agree that hangovers are a result of a disruption to the balance of chemicals in your brain.