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Alpha-GPC increases motivation in healthy volunteers

Alpha GPC 99% memory

For those interested in the dietary supplement Alpha-GPC, a new study has shown that it increases motivation levels in healthy individuals. These findings provide further research into Alpha-GPC 99% and add to the body of evidence on memory retention and learning [1] [2] and membrane repair [3].

Before we dive deeper into this latest study, let's review what Alpha-GPC is, how it works, and why it's gaining in popularity.

Alpha-GPC Facts

  • Alpha-GPC is a natural choline compound found in the human brain.
  • It is the building block to acetylcholine, the chemical your brain releases during cognitive tasks.
  • When orally ingested, it leads to a relative spike in acetylcholine 1-3 hours later [1].
  • Alpha-GPC is recommended for anyone who works in a mentally strenuous role, students who need to study for exams, or anyone interested in increasing acetylcholine levels to support learning, memory retention, and focus [4].
  • Alpha-GPC can cross the blood-brain barrier. This barrier is a border of cells that protects your brain against circulating toxins.
  • According to the National Health and Nutrition Examination Survey (NHANES), up to 90% of Americans do not get enough choline in their diet [5].

The Study

Authors of the randomised, placebo-controlled study undertaken by Hiroshima University in Japan noted that “Alpha-GPC is a precursor of acetylcholine and can increase acetylcholine concentration in the brain.” [6] but the study was particularly interested in how Alpha GPC affected motivation.

Alpha GPC memory learning

A total of 39 healthy volunteers aged 22-59 consisting of 31 females and 8 males participated, reporting their emotional states 3 times a day, every day, for 2 weeks before treatment, and then 2 weeks after. The treatment group took 400mg of 99% Alpha GPC daily whilst the control group a cellulose capsule.

Using a smartphone app they put their 3 x daily feelings into the quadrants below

Results

  • Alpha GPC showed a significant increase in motivation.
  • The placebo control group did not show any changes in motivation
  • Both groups saw a reduction in anxiety
  • The researchers observed no serious side effects in participants whilst also noting in the study that "previous clinical studies showed no serious side effects when human subjects took 1,200 mg/day for six months."
  • The researchers concluded that "Alpha-GPC increased motivation in human subjects without serious side effects, suggesting that Alpha-GPC supplementation has an increased effect on the motivation levels of healthy subjects” [6].

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[1] Schettini G, Ventra C, Florio T, Grimaldi M, Meucci O, Scorziello A, Postiglione A, Marino A. Molecular mechanisms mediating the effects of L-alpha-glycerylphosphorylcholine, a new cognition-enhancing drug, on behavioral and biochemical parameters in young and aged rats. Pharmacol Biochem Behav. 1992 Sep;43(1):139-51. https://pubmed.ncbi.nlm.nih.gov/1409797/ [2] Lopez CM, Govoni S, Battaini F, Bergamaschi S, Longoni A, Giaroni C, Trabucchi M. Effect of a new cognition enhancer, alpha-glycerylphosphorylcholine, on scopolamine-induced amnesia and brain acetylcholine. Pharmacol Biochem Behav. 1991 Aug;39(4):835-40. https://pubmed.ncbi.nlm.nih.gov/1662399/ [3] Institute of Medicine (US) Committee on Nutrition, Trauma, and the Brain; Erdman J, Oria M, Pillsbury L, editors. Nutrition and Traumatic Brain Injury: Improving Acute and Subacute Health Outcomes in Military Personnel. Washington (DC): National Academies Press (US); 2011. 9, Choline.  https://www.ncbi.nlm.nih.gov/books/NBK209327/ [4] University of Granada - Vitamin B: Choline intake improves memory and attention-holding capacity — ScienceDaily July 11, 2013. https://www.sciencedaily.com/releases/2013/07/130711103239.htm# [5] U.S. Department of Agriculture, Agricultural Research Service. Nutrient Intakes from Food and Beverages: Mean Amounts Consumed per Individual, by Gender and Age, What We Eat in America, NHANES 2013-2014. 2016. [6] Tamura, Y.; Takata, K.; Matsubara, K.; Kataoka, Y. Alpha-Glycerylphosphorylcholine Increases Motivation in Healthy Volunteers: A Single-Blind, Randomized, Placebo-Controlled Human Study. Nutrients 202113, 2091. https://doi.org/10.3390/nu13062091 [7] Brain feed (2018) alpha GPC. https://brain-feed.com/alpha-gpc-500mg

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