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5-htp

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5-htp is a natural, isolated nutrient extracted from the Griffonia seed and the building block to your feel-good chemical messenger; serotonin (5-HT). Serotonin plays a vital role in your biochemistry because it helps to regulate mood, At night serotonin is converted into your sleep hormone melatonin to aid sleep.

Our 100mg 5-htp is extracted and isolated from Ghanian Griffonia Simplicifolia seeds. 98% of the tablet is compromised of 5-htp making it the smallest, nutrient-dense tablet available and no unnecessary bulking agents.

  • easy to swallow
  • 100% natural 5-htp from Griffonia seed 

ideal for;

  • Anybody looking to increase their serotonin levels

how it works;

5-HTP is a precursor to the happy hormone called serotonin (5HT). 5HTP goes through a decarboxylase process to be converted to serotonin (5HT). 5HTP can freely cross the blood-brain barrier. It is then freely converted to serotonin.

 

FAQ's
  1. How/when should I take it?
    100mg 5-htp per tablet is a high-quality and high-strength product. It is recommended that you start by taking only 1 tablet with a meal. You can take a maximum of 2 tablets of 5-htp per day. 

  2. How is it different from Tryptophan?
    Tryptophan is another amino acid which is available in small amounts in protein-rich foods such as pork, chicken and beef. In order to be converted into serotonin, it must be converted into 5-htp in the brain however tryptophan is unable to cannot cross the blood-brain barrier. It requires the help of transporter molecules and it competes poorly against other amino acids for this transportation mechanism.

  3. Are there any contra-indications?
    5-htp should not be taken with any anti-depressant medication. Avoid taking 5-htp with Prozac, Zoloft, Paxil, Laxapor, fluoxetine or any form of SSRI.

  4. How long can I take it for?
    +200mg of 5-htp per day have been safely taken for up to one year. We recommend taking 5-htp as/when you have an emotional need for the product. 
ingredients 

5-htp, natural cellulose, magnesium stearate (vegetable source)

studies

[1.] Berumen, L.C., et al., Serotonin Receptors in Hippocampus. The Scientific World Journal, 2012. 2012: p.15.

[2.] Birdsall, T.C., 5-Hydroxytryptophan: A Clinically-Effective Serotonin Precursor. Alternative Medicine Review, 1998. 3(4): p. 271-280.

[3.] Prasad, C., Food, mood and health: a neurobiologic outlook. Brazilian Journal of Medical and Biological Research, 1998. 31: p. 1517-1527.

[4.] Martini, Nath, and Bartholomew, Fundamentals of Anatomy and Physiology. 9th ed, ed. L. Berriman. 2012, San Francisco: Pearson

[5.] Berton, O. and E.J. Nestler, New approaches to antidepressant drug discovery: beyond monoamines. Nat Rev Neurosci, 2006. 7(2): p. 137-151.

[6.] van Praag, H.M., et al., A pilot study of the predictive value of the probenecid test in application of 5-hydroxytryptophan as antidepressant. Psychopharmacologia, 1972. 25(1): p. 14-21.

[7.] Trachte, G.J., T. Uncini, and M. Hinz, Both stimulatory and inhibitory effects of dietary 5-hydroxytryptophan and tyrosine are found on urinary excretion of serotonin and dopamine in a large human population. Neuropsychiatric Disease and Treatment, 2009. 5: p. 227-235.

[8.] von Sano, T., L-5-Hydroxytryptophan-(L-5-HTP) Therapie*. Psychiatry and Clinical Neurosciences, 1972. 26(1): p. 7-17.

[9.] Jangid, P., et al., Comparative study of efficacy of l-5-hydroxytryptophan and fluoxetine in patients presenting with first depressive episode. Asian Journal of Psychiatry, 2013. 6(1): p. 29-34.

[10.]Fujiwara, J. and S. Otsuki, Subtype of Affective Psychoses Classified by Response on Amineprecursors and Monoamine Metabolism. Psychiatry and Clinical Neurosciences, 1974. 28(2): p. 93-100.

[11.] Takahashi, S., H. Kondo, and N. Kato, Effect of L-5-hydroxytryptophan on brain monoamine metabolism and evaluation of its clinical effect in depressed patients. Journal of Psychiatric Research, 1975. 12(3): p. 177-187.

[12.] Nakajima, T., Y. Kudo, and Z. Kaneko, Clinical Evaluation of 5-Hydroxy-L-Tryptophan as an Antidepressant Drug. Psychiatry and Clinical Neurosciences, 1978. 32(2): p. 223-230.

[13.] Alino, J.J., J.L. Gutierrez, and M.L. Iglesias, 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment of depressions. A double-blind controlled study. Int Pharmacopsychiatry, 1976. 11(1): p. 8-15.

[14.]Pöldinger, W., B. Calanchini, and W. Schwarz, A Functional-Dimensional Approach to Depression: Serotonin Deficiency as a Target Syndrome in a Comparison of 5-Hydroxytryptophan and Fluvoxamine. Psychopathology, 1991. 24(2): p. 53-81.

[15.] Bell, E.A. and D.H. Janzen, Medical and Ecological Considerations of L-Dopa and 5-HTP in Seeds. Nature, 1971. 229(5280): p. 136-137.

[16.] Biskup, C.S., et al., Effects of Acute Tryptophan Depletion on Brain Serotonin Function and Concentrations of Dopamine and Norepinephrine in C57BL/6J and BALB/cJ Mice. PLoS ONE, 2012. 7(5): p. e35916.

 

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