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Alpha GPC Choline 99%

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Alpha Glyceryl Phosphoryl Choline is a potent form of the nutrient choline because it can cross the blood-brain barrier. It is the immediate precursor to the brain's chemical messenger acetylcholine which is released when conducting cognitive tasks such as memory retention or learning.

The world’s 1st 500mg Alpha GPC capsule containing 99% Alpha GPC* (the purest form of Alpha GPC)

ideal for;

The ideal nootropic for anybody with a mentally strenuous role, students or professionals who are studying for exams or anybody looking for a vegan choline supplement. 

how it works;

Food derived choline and other forms of choline such as choline bitartrate cannot cross the blood-brain barrier alone. These forms of choline require a specific carrier mechanism that transports free choline across the BBB and only at a rate that is proportional to serum choline concentration [1]

Alpha GPC is an isolated nutrient that naturally occurs in the brain. It also freely crosses the blood-brain barrier to directly support acetylcholine production.

  • Boosting choline levels can help to restore the bioavailability of acetylcholine [6,7]
  • Acetylcholine is essential for cognitive function, and it is essential for memory recall. Supplementation with Alpha GPC indicated an increase in brain function directly related to the healthy supply of acetylcholine [17]

*[launched 1st June 2018] 

  1. How do I take it?
    Take 1 capsule per day with food. Ideally in the morning, at lunch or just before you start work.

  2. Could I be choline deficient?
    In 2014 the US National Centers for Disease Control and Prevention claimed that 90% of Americans are not getting enough choline in their diet. US Adequate Intake levels for men are 550mg/day and for women 425mg/day. In the EU it’s 480mg/day for pregnant women and 520mg/day for lactating women.

  3. How long does it take to have an effect?
    When orally ingested it shows a relative spike in acetylcholine 1-3 hours post-ingestion. [17]

  4. Short term - what should I notice?
    You may notice an ability to work for longer and an improved speed of recall.

  5. Long term - what should I notice?
    Double-blind placebo-controlled studies into patients with mild to moderate Alzheimer’s Dementia showed Alpha GPC was able to improve cognitive symptoms as assessed by 4 different rating scales for cognition. [4]

  6. How long can I take it for?

    A double-blind placebo-controlled study into Alpha GPC tested 180 days of continuous supplementation without adverse effects. [15] 

  7. How much Choline is Alpha GPC? And, how does it compare?
    • Our 99% Alpha GPC encapsulation is 40% Choline by weight.
    • Most Alpha GPC products use a 50% Alpha GPC which is ½ bulking agent ½ Alpha GPC. They only contain 20% choline
    • CDP choline is 18.5% choline
    • Citicoline is 18.5% choline 

  8. Are there any other benefits to choline?
    Yes; choline contributes to the maintenance of normal liver function, normal homocysteine metabolism and lipid metabolism. However, the evidence for strength and conditioning training and improvements in sports performance is too limited. 

  9. Are there any side effects?
    Alpha GPC is safe when taken at the recommended dose. It is not recommended to exceed the stated dose. At higher than recommended doses a small number of people may experience side effects such as headaches or dizziness.

    Alpha GPC (99%), mannitol, vegetable cellulose capsule (HPMC), silicon dioxide, Magnesium stearate, vitamin B12


    [1] University of Granada. - Vitamin B: Choline intake improves memory and attention-holding capacity – ScienceDaily 11 July 2013.

    [2] Barbagallo Sangiorgi G, Barbagallo M, Giordano M, et al. Alpha-glycerophosphocholine in the mental recovery of cerebral ischemic attacks: An Italian multicenter clinical trial. Ann N Y Acad Sci 1994;717:253-69.

    [3] Steven Zeisel – The fetal origins of memory: the role of dietary choline in optimal brain development - Journal of Paediatrics 2006 November 149 (5) S131

    [4] Lopez CM, Govoni S, Battaini F, Bergamaschi S, Longoni A, Giaroni C. Effect of a new cognition enhancer, alpha-glycerylphosphorylcholine, on scopolamine-induced amnesia and brain acetylcholine. Pharmacol Biochem Behav 1991 Aug;39(4):835-40.

    [5] Gatti G, Barzaghi N, Acuto G, et al. A comparative study of free plasma choline levels following intramuscular administration of L-alpha-glycerylphosphorylcholine and citocoline in normal volunteers. Int J Clin Pharmacol Ther Toxicol 1992;30:331-5.

    [6] Trabucchi M, Govoni S, Battaini F. Changes in the interaction between CNS cholinergic and dopaminergic neurons induced by L-alpha-glycerylphosphorylcholine, a cholinomimetic drug.Farmaco [Sci] 1986 Apr;41(4):325-34

    [7] Vega JA, Cavallotti C, del Valle ME, Mancini M, Amenta F. Nerve growth factor receptor immunoreactivity in the cerebellar cortex of aged rats: effect of choline alfoscerate treatment. Mech Ageing Dev 1993 Jun;69(1-2):119-27.

    [8] Amenta F, Ferrante F, Vega JA, Zaccheo D.Long term choline alfoscerate treatment counters age-dependent microanatomical changes in rat brain. Prog Neuropsychopharmacol Biol Psychiatry. 1994 Sep;18(5):915-24.

    [9] Amenta F et al Age-related structural changes in the rat cerebellar cortex: effect of choline alfoscerate treatment. Mech Ageing Dev 1991 Dec 2;61(2):173-86

    [10] Hayarelis Moreno et al - Chronic dietary choline supplementation modulates attentional change in adult rats Behavioural Brain Research Volume 243 15th 2013 

    [11] Steven Zeisel - Nutrition in pregnancy: the argument for including a source of choline International Journal for Womens Health 2013; 5 193-199

    [12] Mihai D Niculescu -  Perintal Choline Influences Brain Structure and Function – Nutrition Review 2006 April 64 (4) 197-203

    [13] Steven Zeisel - Is maternal diet supplementation beneficial? Optimal development of infant depends on mother's diet – The American Journal of Clinical Nutrition 2009 February: 89(2) 685-687

    [14] Abbiati, G.; Fossati, T.; Arrigoni, M.; Rolle, P.; Dognini, G. L.;Castiglioni, C. High-performance liquid chromatographic assay of L-alpha-glycerophosphorylcholine using a two-step enzymatic conversion. J. Chromatogr. Biomed. Applic., in press; 1991.

    [15] Maria Moreno - Cognitive improvement in mild to moderate Alzheimer's dementia after treatment with the acetylcholine precursor choline alfoscerate: A multicenter, double-blind, randomized, placebo-controlled trial Journal of Clinical Therapeutics 2003 Vol 25

    [16] Drago F et al. Behavioral effects of L-alpha-glycerylphosphorylcholine: influence on cognitive mechanisms in the rat. Pharmacol Biochem Behav1992 Feb;41(2):445-8.

    [17] Schettini G, et al Molecular mechanisms mediating the effects of L-alpha-glycerylphosphorylcholine, a new cognition-enhancing drug, on behavioral and biochemical parameters in young and aged rats. Pharmacol Biochem Behav 1992 Sep;43(1):139-51.

    [18] Lopez CM et al Effect of a new cognition enhancer, alpha-glycerylphosphorylcholine, on scopolamine-induced amnesia and brain acetylcholine. Pharmacol Biochem Behav 1991 Aug;39(4):835-40.

    [19] Amenta F et al cholinergic receptors in the hippocampus of aged rats: influence of choline alphoscerate treatment. Mech Ageing Dev 1994 Oct 1;76(1):49-64

    [20] Amenta F, et al Cholinergic neurotransmission in the hippocampus of aged rats: influence of L-alpha-glycerylphosphorylcholine treatment. Ann N Y Acad Sci1993 Sep  4;695:311-3

    [21] Bronzetti E et al Effect of ipsilateral lesioning of the nucleus basalis magnocellularis and of L-alpha-glyceryl phosphorylcholine treatment on choline acetyltransferase and acetylcholinesterase in the rat fronto-parietal cortex. Neurosci Lett1993 Dec 24;164(1-2):47-50

    [22] R. Di Perri et al A multicentre trial to evaluate the efficacy & tolerability of Alpha GPC versus CDP in patients with vascular Dementia - Journal of International Medical Research 1991 July Vol; 19 issue 4 330-341


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