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Alpha GPC supplement Alpha gpc benefits acetylcholine supplement

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Alpha GPC Choline 99%

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Regular price £29.99

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30 capsules

60 capsules

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The world’s 1st 500mg Alpha GPC capsules containing 99% Alpha GPC. Alpha GPC is the building block of acetylcholine [1], your memory and learning chemical [2], making it an ideal nootropic for anyone in a mentally strenuous role, including students, professionals studying for exams, or those seeking a vegan choline supplement.

500mg Alpha GPC per capsule
Crosses the blood-brain barrier [3]
Increases acetylcholine in 1–3 hours [3]
1-a-day
99% Alpha GPC

Many Alpha-GPC supplements and powders use a 50% Alpha GPC blend to simplify the manufacturing process reducing potential benefits. Our Alpha-GPC is manufactured in an FDA-registered facility in the UK under strict GMP, ISO 9001, and ISO 22000 certified conditions.

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what is Alpha GPC?

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Alpha-GlycerylPhosphorylCholine (Alpha GPC) is a potent form of the nutrient choline, favoured for its ability to freely enter the brain and convert into acetylcholine. Although its scientific-sounding name, Alpha GPC is entirely natural and occurs in small amounts in various dietary sources, including egg yolks [4] and even breast milk [5].

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Alpha GPC is the best source of choline for brain health as it easily crosses the brain's protective blood-brain barrier [6]. Food-derived choline and other choline supplements like choline bitartrate are unable to enter the brain independently [7]. They rely on a specific carrier mechanism making Alpha GPC choline a more efficient and direct way to increase acetylcholine.

After oral ingestion, Alpha GPC effects last about 6 hours [8].

Alpha GPC benefits

An analysis of 8 studies on Alpha GPC supplementation for cognitive impairment revealed that participants showed improved scores on measures of cognition, behaviour, and functionality [9].

Additionally, a comprehensive review of 29 years of research involving over 400 participants found that Alpha GPC improved memory scores [10].

^{*Although studies have been positive, there is no European health claim for Alpha GPC and cognition.}

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what is acetylcholine ?

Memory, learning and recalling information are all part of acetylcholine’s function. Released when conducting cognitive tasks, acetylcholine is essential for cognitive function and memory recall [11,12].

Higher levels of acetylcholine are associated with feelings of mental sharpness whereas low levels of acetylcholine are associated with cognitive challenges [13].

how to increase acetylcholine ?

Acetylcholine production depends on your dietary choline intake [14]. To increase your levels of acetylcholine, supplements that contain forms of choline that can freely enter the brain are highly effective. It is recommended to take Alpha GPC 1 hour before engaging in specific cognitive tasks, like studying or working on complex projects.

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1. Brandt, N., & Flurie, R. (2020). Acetylcholine. In M. D. Gellman (Ed.), Encyclopedia of Behavioral Medicine (pp. 18–19). Springer International Publishing. https://link.springer.com/referenceworkentry/10.1007/978-3-030-39903-0_1351

2. Hasselmo, M. E. (2006). The role of acetylcholine in learning and memory. Current Opinion in Neurobiology, 16(6), 710–715. https://www.sciencedirect.com/science/article/abs/pii/S095943880600122X?via%3Dihub

3. Schettini, G., Ventra, C., Florio, T., Grimaldi, M., Meucci, O., Scorziello, A., Postiglione, A., & Marino, A. (1992). Molecular mechanisms mediating the effects of l-α-glycerylphosphorylcholine, a new cognition-enhancing drug, on behavioral and biochemical parameters in young and aged rats. Pharmacology Biochemistry and Behavior, 43(1), 139–151. https://www.sciencedirect.com/science/article/abs/pii/0091305792906505?via%3Dihub

4. Yamashita, S., Kawada, N., Wang, W., Susaki, K., Takeda, Y., Kimura, M., Iwama, Y., Miura, Y., Sugano, M., & Matsuoka, R. (2023). Effects of egg yolk choline intake on cognitive functions and plasma choline levels in healthy middle-aged and older Japanese: A randomized double-blinded placebo-controlled parallel-group study. Lipids in Health and Disease, 22, 75. https://lipidworld.biomedcentral.com/articles/10.1186/s12944-023-01844-w

5. Moukarzel, S., Wiedeman, A. M., Soberanes, L. S., Dyer, R. A., Innis, S. M., & Lamers, Y. (2019). Variability of Water-Soluble Forms of Choline Concentrations in Human Milk during Storage, after Pasteurization, and among Women. Nutrients, 11(12), Article 12. https://www.mdpi.com/2072-6643/11/12/3024

6. Tamura, Y., Takata, K., Matsubara, K., & Kataoka, Y. (2021). Alpha-Glycerylphosphorylcholine Increases Motivation in Healthy Volunteers: A Single-Blind, Randomized, Placebo-Controlled Human Study. Nutrients, 13(6), 2091. https://www.mdpi.com/2072-6643/13/6/2091

7. University of Granada. - Vitamin B: Choline intake improves memory and attention-holding capacity – ScienceDaily 11 July 2013.

8. Parnetti, L., Mignini, F., Tomassoni, D., Traini, E., & Amenta, F. (2007). Cholinergic precursors in the treatment of cognitive impairment of vascular origin: Ineffective approaches or need for re-evaluation? Journal of the Neurological Sciences, 257(1–2), 264–269. https://doi.org/10.1016/j.jns.2007.01.043

9. Sagaro, G. G. et al. (2023). Activity of Choline Alphoscerate on Adult-Onset Cognitive Dysfunctions: A Systematic Review and Meta-Analysis. Journal of Alzheimer's disease, 92(1), 59-70. https://www.jns-journal.com/article/S0022-510X(07)00059-7/abstract

10. Sagaro, G. G., Traini, E., & Amenta, F. (2023). Activity of Choline Alphoscerate on Adult-Onset Cognitive Dysfunctions: A Systematic Review and Meta-Analysis. Journal of Alzheimer’s Disease, 92(1), 59–70. https://journals.sagepub.com/doi/full/10.3233/JAD-221189

11. Hasselmo M. E. (2006). The role of acetylcholine in learning and memory. Current opinion in neurobiology, 16(6), 710–715. https://www.sciencedirect.com/science/article/abs/pii/S095943880600122X?via%3Dihub

12. Newman, E., L., Gupta, K., Climer, J., R., Monaghan, C., K., & Hasselmo, M., E. (2012). Cholinergic modulation of cognitive processing: insights drawn from computational models. Frontiers in Behavioral Neuroscience, 6, 24. https://www.frontiersin.org/journals/behavioral-neuroscience/articles/10.3389/fnbeh.2012.00024/full

13. Haam, J., & Yakel, J. L. (2017). Cholinergic modulation of the hippocampal region and memory function. Journal of neurochemistry, 142(Suppl 2), 111–121. https://onlinelibrary.wiley.com/doi/10.1111/jnc.14052

14. Chung, S. Y., Moriyama, T., Uezu, E., Uezu, K., Hirata, R., Yohena, N., Masuda, Y., Kokubu, T., & Yamamoto, S. (1995). Administration of phosphatidylcholine increases brain acetylcholine concentration and improves memory in mice with dementia. The Journal of nutrition, 125(6), 1484–1489. https://www.sciencedirect.com/science/article/abs/pii/S0022316623035605

15. Lopez CM, Govoni S, Battaini F, Bergamaschi S, Longoni A, Giaroni C. Effect of a new cognition enhancer, alpha-glycerylphosphorylcholine, on scopolamine-induced amnesia and brain acetylcholine. Pharmacol Biochem Behav 1991 Aug;39(4):835-40.

16. Maria Moreno - Cognitive improvement in mild to moderate Alzheimer's dementia after treatment with the acetylcholine precursor choline alfoscerate: A multicenter, double-blind, randomized, placebo-controlled trial Journal of Clinical Therapeutics 2003 Vol 25

FAQ's

How do I take it?

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Take 1 capsule per day with food (500mg Alpha GPC/dose). Ideally in the morning, at lunch or just before you start work.

Short term - what should I notice?

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You may notice an ability to work for longer and an improved speed of recall.

How much Choline is Alpha GPC? And, how does it compare?

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Our Alpha GPC 99% encapsulation is 40% Choline by weight.Most Alpha GPC products use a 50% Alpha GPC which is ½ bulking agent ½ Alpha GPC. They only contain 20% choline
CDP choline is 18.5% choline
Citicholine is 18.5% choline

Why does it include magnesium stearate & B12 ?

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All of our products are vegan. For people that follow a vegan diet, they are at a higher risk of choline deficiency [1] and this is often a coupled with B12 deficiency. Vegans must supplement with B12 in order to obtain the recommended daily intake. Magnesium stearate is a flow agent and it is vital to ensure that each capsule contains 500mg of Alpha GPC

Could I be choline deficient?

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In 2014 the US National Centers for Disease Control and Prevention claimed that 90% of Americans are not getting enough choline in their diet. US Adequate Intake levels for men are 550mg/day and for women 425mg/day. In the EU it’s 480mg/day for pregnant women and 520mg/day for lactating women.

Long term - what should I notice?

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Double-blind placebo-controlled studies into patients with mild to moderate Alzheimer’s Dementia showed Alpha GPC was able to improve cognitive symptoms as assessed by 4 different rating scales for cognition. [15]

Are there any other benefits of choline?

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Yes; choline contributes to the maintenance of normal liver function, normal homocysteine metabolism and lipid metabolism. However, the evidence for strength and conditioning training and improvements in sports performance is too limited.

How long does Alpha GPC take to work ?

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When orally ingested it shows a relative spike in acetylcholine 1-3 hours post-ingestion. [3]

Is Alpha GPC safe ? How long can I take it for ?

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A double-blind placebo-controlled study into Alpha GPC tested 180 days of continuous supplementation without adverse effects. [16]

Are there any side effects of Alpha GPC ?

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Alpha GPC is safe when taken at the recommended dose. It is not recommended to exceed the stated dose. At higher than recommended doses a small number of people may experience side effects such as headaches or dizziness.

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Dec 5, 2024

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