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5-htp 100mg Tablets

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5-HTP is a natural, isolated nutrient extracted from Ghanaian-sourced Griffonia seeds and it is the essential building block to your feel good chemical messenger; serotonin (5-HT). Serotonin plays a crucial role in regulating mood[1]. At night, serotonin is converted into melatonin to aid sleep[2,3].

Our 5-HTP 100mg tablets contain 99% 5-HTP making it the smallest and nutrient-dense 5-htp supplement available. They are free from unnecessary bulking agents and are manufactured in an FDA-registered facility in the UK under strict GMP, ISO 9001, and ISO 22000 certified conditions.

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what is 5HTP?

5HTP, is naturally created in the body from the dietary consumption of protein-rich foods which contain the amino acid tryptophan. Whilst both are building blocks to serotonin, 5HTP provides a more direct and efficient route to increasing serotonin levels because :

It can freely cross your brain’s protective layer known as the blood-brain-barrier [4].
Tryptophan must bind with a transporter molecule to enter the brain. It competes poorly with other nutrients for this molecule hindering its entry [5].
95% of serotonin is produced in the gut [6]. Serotonin produced in the digestive tract is unable to enter the brain or directly influence mood.

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As a result, the brain relies on its own internal production of serotonin [7]. This is why supplements to increase serotonin, such as 5HTP, support healthy serotonin levels in the brain and are considered effective serotonin supplements.

In the US and Canada, 5HTP is categorised as a dietary supplement for mood support, while in the UK, it is considered a food supplement. In Ireland, Denmark, and Japan it’s classified as a medicine.

what is serotonin ?

Serotonin is a neurotransmitter naturally produced in your body . Higher serotonin levels are associated with feeling positive whereas low serotonin levels have been linked to mood and sleep disorders [8,9,10,11]. Factors that can influence your serotonin levels include :

Dietary intake of tryptophan or 5HTP [12]
Functioning of your brain’s serotonin receptors
Genetics [13,14]
Inflammation [15]
Chronic stress [16]

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what does serotonin do in the brain ?

serotonin supplement 5htp anxiety what is serotonin

Happiness, joy and a sense of contentment are all part of serotonin's role in regulating mood. Likewise, serotonin plays a role in regulating sleep patterns as it’s the building block of your sleep hormone melatonin[17].

Elsewhere in the body serotonin plays a role in appetite control, helping to regulate feelings of hunger and satiety [18].

how to stimulate serotonin release?

Before you can release serotonin, ensure your body has enough of its building blocks, as adequate production is necessary to reap its feel good effects. Serotonin’s release is stimulated by activities including :

Exercise – Mice that ran on treadmills had higher brain serotonin levels compared to sedentary mice [19].
Social interaction - Feelings of belonging and emotional support are linked to higher serotonin [20]. Caring for others, through volunteering or nurturing loved ones, may also provide a serotonin lift [20].
Listening to music - In adults, pleasant music increased serotonin levels compared to unpleasant music [21]
Sunlight - Serotonin levels are higher in the summer compared to winter, likely due to increased sunlight exposure.
Physical touch - Getting regular massages can increase your serotonin levels by up to 30% [22].

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1.Jenkins, T. A., Nguyen, J. C. D., Polglaze, K. E., & Bertrand, P. P. (2016). Influence of Tryptophan and Serotonin on Mood and Cognition with a Possible Role of the Gut-Brain Axis. Nutrients, 8(1), 56. https://doi.org/10.3390/nu8010056

2. Siegel, J. M. (2004). The Neurotransmitters of Sleep. The Journal of Clinical Psychiatry, 65(Suppl 16), 4. https://pubmed.ncbi.nlm.nih.gov/15575797/

3. Lee, B. H., Hille, B., & Koh, D.-S. (2021). Serotonin modulates melatonin synthesis as an autocrine neurotransmitter in the pineal gland. Proceedings of the National Academy of Sciences, 118(43), e2113852118. https://doi.org/10.1073/pnas.2113852118

4.Sjögren, M., Skovgaard Møller Nielsen, A., Collin Hasselbalch, K., Wøllo, M., & Stilund Hansen, J. (2019). A systematic review of blood-based serotonergic biomarkers in Bulimia Nervosa. Psychiatry Research, 279, 155–171. https://doi.org/10.1016/j.psychres.2018.12.167

5. Pratt, O.E. (1979). Kinetics of Tryptophan Transport Across the Blood-Brain Barrier. In: P. Baumann (Ed.), Transport Mechanisms of Tryptophan in Blood Cells, Nerve Cells, and at the Blood-Brain Barrier. Journal of Neural Transmission, 15. Springer, Vienna. https://doi.org/10.1007/978-3-7091-2243-3_3

6. Appleton, J. (2018). The Gut-Brain Axis: Influence of Microbiota on Mood and Mental Health. Integrative Medicine: A Clinician’s Journal, 17(4), 28–32. https://pubmed.ncbi.nlm.nih.gov/31043907/

7. Andrews, P. W., Bosyj, C., Brenton, L., Green, L., Gasser, P. J., Lowry, C., A., & Pickel, V. M. (2022). All the brain's a stage for serotonin: the forgotten story of serotonin diffusion across cell membranes. Proceedings of the Royal Socciety B, 289(1986), 28920221565.http://doi.org/10.1098/rspb.2022.1565

8. Whitaker-Azmitia, P. M. (1999). The Discovery of Serotonin and its Role in Neuroscience. Neuropsychopharmacology, 21(1), 2–8. https://doi.org/10.1016/S0893-133X(99)00031-7

9.Solarewicz, J. Z., Angoa-Perez, M., Kuhn, D. M., & Mateika, J. H. (2015). The sleep-wake cycle and motor activity, but not temperature, are disrupted over the light-dark cycle in mice genetically depleted of serotonin. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 308(1), R10–R17. https://doi.org/10.1152/ajpregu.00400.2014

10.Wieckiewicz, M., Martynowicz, H., Lavigne, G., Lobbezoo, F., Kato, T., Winocur, E., Wezgowiec, J., Danel, D., Wojakowska, A., Mazur, G., & Smardz, J. (2023). An exploratory study on the association between serotonin and sleep breathing disorders. Scientific Reports, 13, 11800. https://doi.org/10.1038/s41598-023-38842-y

11. Leu-Semenescu, S., Arnulf, I., Decaix, C., Moussa, F., Clot, F., Boniol, C., Touitou, Y., Levy, R., Vidailhet, M., & Roze, E. (2010). Sleep and Rhythm Consequences of a Genetically Induced Loss of Serotonin. Sleep, 33(3), 307–314. https://doi.org/10.1093/sleep/33.3.307

12. Jenkins, T. A., Nguyen, J. C. D., Polglaze, K. E., & Bertrand, P. P. (2016). Influence of Tryptophan and Serotonin on Mood and Cognition with a Possible Role of the Gut-Brain Axis. Nutrients, 8(1), 56. https://doi.org/10.3390/nu8010056

13. Nordquist, N., & Oreland, L. (2010). Serotonin, genetic variability, behaviour, and psychiatric disorders—A review. Upsala Journal of Medical Sciences, 115(1), 2–10. https://doi.org/10.3109/03009730903573246

14. Bruzzone, S. E. P., Nasser, A., Aripaka, S. S., Spies, M., Ozenne, B., Jensen, P. S., Knudsen, G. M., Frokjaer, V. G., & Fisher, P. M. (2023). Genetic contributions to brain serotonin transporter levels in healthy adults. Scientific Reports, 13, 16426. https://doi.org/10.1038/s41598-023-43690-x

15. Wichers, M. C., & Maes, M. (2004). The role of indoleamine 2,3-dioxygenase (IDO) in the pathophysiology of interferon-alpha-induced depression. Journal of psychiatry & neuroscience, 29(1), 11–17. https://www.jpn.ca/content/29/1/11.

16. long Chaouloff, F., Berton, O., & Mormède, P. (1999). Serotonin and Stress. Neuropsychopharmacology, 21(1), 28–32. https://doi.org/10.1016/S0893-133X(99)00008-1

17. Lee, B. H., Hille, B., & Koh, D.-S. (2021). Serotonin modulates melatonin synthesis as an autocrine neurotransmitter in the pineal gland. Proceedings of the National Academy of Sciences, 118(43), e2113852118. https://doi.org/10.1073/pnas.2113852118

18. Leibowitz, S. F., & Alexander, J. T. (1998). Hypothalamic serotonin in control of eating behavior, meal size, and body weight. Biological psychiatry, 44(9), 851–864. https://doi.org/10.1016/s0006-3223(98)00186-3

19. Alizadeh Pahlavani, H. (2024). Possible role of exercise therapy on depression: Effector neurotransmitters as key players. Behavioural Brain Research, 459, 114791. https://doi.org/10.1016/j.bbr.2023.114791

20. Evers, S., & Suhr, B. (2000). Changes of the neurotransmitter serotonin but not of hormones during short time music perception. European archives of psychiatry and clinical neuroscience, 250(3), 144–147. https://doi.org/10.1007/s004060070031

21. Association between salivary serotonin and the social sharing of happiness. PLOS ONE, 12(7), e0180391 .https://doi.org/10.1371/journal.pone.0180391

22.Field, T. et al. (2005). Cortisol decreases and serotonin and dopamine increase following massage therapy. The International journal of neuroscience, 115(10), 1397–1413. https://doi.org/10.1080/00207450590956459

FAQ's

When should I take 5htp ?

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100mg 5-htp per tablet is a high-quality and high-strength product. It is recommended that you start by taking only 1 tablet with a meal. You can take a maximum of 2 tablets of 5-htp per day.

We recommend you take 5HTP when you have an emotional need for the product. The mornings are better if you want support throughout the day. It can also be taken in the evening as at night the body converts serotonin into melatonin.

Is 5htp safe ? How long can I take it for ?

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+200mg of 5-htp per day have been safely taken for up to one year. We recommend taking 5-htp as/when you have an emotional need for the product.

5htp vs tryptophan - can you take serotonin tablets ?

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Tryptophan is another amino acid which is available in small amounts in protein-rich foods such as pork, chicken and beef. In order to be converted into serotonin, it must be converted into 5-htp in the brain however tryptophan is unable to cannot cross the blood-brain barrier. It requires the help of transporter molecules and it competes poorly against other amino acids for this transportation mechanism.

Are there any 5-htp side effects or contraindications ?

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5-htp should not be taken with any anti-depressant medication.

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Jun 18, 2024

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