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Alpha GPC supplement Alpha gpc benefits acetylcholine supplement

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Alpha GPC Choline 99%

Name: Alpha GPC Choline 99%
Rating: 4.2 (169 reviews)

Regular price £29.99

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Size

30 capsules

60 capsules

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World’s 1st 500mg Alpha GPC capsules containing 99% Alpha GPC. Alpha GPC is the building block of your memory and learning chemical, acetylcholine [1,2]. Acetylcholine supports memory formation, retention and retrieval [2].

500mg Alpha GPC 99% per capsule
1-a-day. Single capsule dose
Increases acetylcholine in 1–3 hours [3] with effects lasting up to 6 hours [4]
Ideal nootropic for mentally demanding roles, professionals, students or as a vegan choline supplement
Crosses the blood-brain barrier [3]

Many Alpha-GPC supplements and powders use a 50% Alpha GPC blend to simplify the manufacturing process reducing potential benefits. Our Alpha-GPC is manufactured in an FDA-registered facility in the UK under strict GMP, ISO 9001, and ISO 22000 certified conditions.

31 studies confirm Alpha GPC supports acetylcholine

brain feed analysed 31 published trials which confirmed Alpha GPC supports the production and function of acetylcholine. Backed by science, proven by research.

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*brain feed does not test or commission studies on animals. This is an analysis of pre-existing studies.

what is Alpha GPC?

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Alpha-GlycerylPhosphorylCholine (Alpha GPC) is a potent form of the nutrient choline, favoured for its ability to freely enter the brain and convert into acetylcholine. Although its scientific-sounding name, Alpha GPC is entirely natural and occurs in small amounts in various dietary sources, including egg yolks [5] and even breast milk [6].

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Alpha GPC is the best source of choline for brain health as it easily crosses the brain's protective blood-brain barrier [7]. Food-derived choline and other choline supplements like choline bitartrate are unable to enter the brain independently [8]. They rely on a specific carrier mechanism making Alpha GPC choline a more efficient and direct way to increase acetylcholine.

Alpha GPC benefits

An analysis of 8 studies on Alpha GPC supplementation for cognitive impairment revealed that participants showed improved scores on measures of cognition, behaviour, and functionality [9].

Additionally, a comprehensive review of 29 years of research involving over 400 participants found that Alpha GPC improved memory scores [10].

^{*Although studies have been positive, there is no European health claim for Alpha GPC and cognition.}

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★★★★★

"- it's a 99% alpha GPC compared to most formulations which use a 50% alpha GPC blend and it's the only one I've found which is strong enough to work..."

J -01/08/19

★★★★★

"...Helped me study in 2 days the whole material for a semester... "

Vic - 31/05/2021

★★★★★

" I take it once a day after breakfast. I have tried maybe 5 different productions in my life, this one is with real effect, I recommend it!"

Marina - 07/09/2023

track your progress

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Track how Alpha GPC works for you over time. Adapted from research methods used in over 30 clinical trials across 25 years, brain feed’s user-friendly self-assessments deliver near-instant results. Monitor your brain health through a simple 3-step process, included with your first Alpha GPC order, to track results at baseline, 1 day, and 30 days

what is acetylcholine ?

Memory, learning and recalling information are all part of acetylcholine’s function. Released when conducting cognitive tasks, acetylcholine is essential for cognitive function and memory recall [11,12].

Higher levels of acetylcholine are associated with feelings of mental sharpness whereas low levels of acetylcholine are associated with cognitive challenges [13].

how to increase acetylcholine ?

Acetylcholine production depends on your dietary choline intake [14]. To increase your levels of acetylcholine, supplements that contain forms of choline that can freely enter the brain are highly effective. It is recommended to take Alpha GPC 1 hour before engaging in specific cognitive tasks, like studying or working on complex projects.

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1. Brandt, N., & Flurie, R. (2020). Acetylcholine. In M. D. Gellman (Ed.), Encyclopedia of Behavioral Medicine (pp. 18–19). Springer International Publishing. https://link.springer.com/referenceworkentry/10.1007/978-3-030-39903-0_1351

2. Hasselmo, M. E. (2006). The role of acetylcholine in learning and memory. Current Opinion in Neurobiology, 16(6), 710–715. https://www.sciencedirect.com/science/article/abs/pii/S095943880600122X?via%3Dihub

3. Schettini, G., Ventra, C., Florio, T., Grimaldi, M., Meucci, O., Scorziello, A., Postiglione, A., & Marino, A. (1992). Molecular mechanisms mediating the effects of l-α-glycerylphosphorylcholine, a new cognition-enhancing drug, on behavioral and biochemical parameters in young and aged rats. Pharmacology Biochemistry and Behavior, 43(1), 139–151. https://www.sciencedirect.com/science/article/abs/pii/0091305792906505?via%3Dihub

4. Böckmann, K. A., Franz, A. R., Minarski, M., Shunova, A., Maiwald, C. A., Schwarz, J., Gross, M., Poets, C. F., & Bernhard, W. (2022). Differential metabolism of choline supplements in adult volunteers. European journal of nutrition, 61(1), 219–230. https://link.springer.com/article/10.1007/s00394-021-02637-6

5. Yamashita, S., Kawada, N., Wang, W., Susaki, K., Takeda, Y., Kimura, M., Iwama, Y., Miura, Y., Sugano, M., & Matsuoka, R. (2023). Effects of egg yolk choline intake on cognitive functions and plasma choline levels in healthy middle-aged and older Japanese: A randomized double-blinded placebo-controlled parallel-group study. Lipids in Health and Disease, 22, 75. https://lipidworld.biomedcentral.com/articles/10.1186/s12944-023-01844-w

6. Moukarzel, S., Wiedeman, A. M., Soberanes, L. S., Dyer, R. A., Innis, S. M., & Lamers, Y. (2019). Variability of Water-Soluble Forms of Choline Concentrations in Human Milk during Storage, after Pasteurization, and among Women. Nutrients, 11(12), Article 12. https://www.mdpi.com/2072-6643/11/12/3024

7. Tamura, Y., Takata, K., Matsubara, K., & Kataoka, Y. (2021). Alpha-Glycerylphosphorylcholine Increases Motivation in Healthy Volunteers: A Single-Blind, Randomized, Placebo-Controlled Human Study. Nutrients, 13(6), 2091. https://www.mdpi.com/2072-6643/13/6/2091

8. University of Granada. - Vitamin B: Choline intake improves memory and attention-holding capacity – ScienceDaily 11 July 2013.

9. Sagaro, G. G. et al. (2023). Activity of Choline Alphoscerate on Adult-Onset Cognitive Dysfunctions: A Systematic Review and Meta-Analysis. Journal of Alzheimer's disease, 92(1), 59-70. https://www.jns-journal.com/article/S0022-510X(07)00059-7/abstract

10. Sagaro, G. G., Traini, E., & Amenta, F. (2023). Activity of Choline Alphoscerate on Adult-Onset Cognitive Dysfunctions: A Systematic Review and Meta-Analysis. Journal of Alzheimer’s Disease, 92(1), 59–70. https://journals.sagepub.com/doi/full/10.3233/JAD-221189

11. Hasselmo M. E. (2006). The role of acetylcholine in learning and memory. Current opinion in neurobiology, 16(6), 710–715. https://www.sciencedirect.com/science/article/abs/pii/S095943880600122X?via%3Dihub

12. Newman, E., L., Gupta, K., Climer, J., R., Monaghan, C., K., & Hasselmo, M., E. (2012). Cholinergic modulation of cognitive processing: insights drawn from computational models. Frontiers in Behavioral Neuroscience, 6, 24. https://www.frontiersin.org/journals/behavioral-neuroscience/articles/10.3389/fnbeh.2012.00024/full

13. Haam, J., & Yakel, J. L. (2017). Cholinergic modulation of the hippocampal region and memory function. Journal of neurochemistry, 142(Suppl 2), 111–121. https://onlinelibrary.wiley.com/doi/10.1111/jnc.14052

14. Chung, S. Y., Moriyama, T., Uezu, E., Uezu, K., Hirata, R., Yohena, N., Masuda, Y., Kokubu, T., & Yamamoto, S. (1995). Administration of phosphatidylcholine increases brain acetylcholine concentration and improves memory in mice with dementia. The Journal of nutrition, 125(6), 1484–1489. https://www.sciencedirect.com/science/article/abs/pii/S0022316623035605

15. Lopez CM, Govoni S, Battaini F, Bergamaschi S, Longoni A, Giaroni C. Effect of a new cognition enhancer, alpha-glycerylphosphorylcholine, on scopolamine-induced amnesia and brain acetylcholine. Pharmacol Biochem Behav 1991 Aug;39(4):835-40.

16. Maria Moreno - Cognitive improvement in mild to moderate Alzheimer's dementia after treatment with the acetylcholine precursor choline alfoscerate: A multicenter, double-blind, randomized, placebo-controlled trial Journal of Clinical Therapeutics 2003 Vol 25

purity promise™

Purity has four components:

1. brain feed ensures the high quality of our extracts and isolates through rigorous testing
2. We monitor critical control points during production for quality control
3. We guarantee the amount of active ingredient(s)
4. Preserve the bio-active compounds for the duration of their shelflife.

Click here to read more

NutriProtect™

Nutriprotect™ is our innovative capsule technology with additional UV protection built into the shell. It improves nutrient stability, allowing us to remove a permanent UV barrier used in composite packaging materials. The net result: fully recyclable pouches. Click here to read more.

FAQ's

How do I take it?

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Take 1 capsule per day with food (500mg Alpha GPC/dose). Ideally in the morning, at lunch or just before you start work.

Short term - what should I notice?

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You may notice an ability to work for longer and an improved speed of recall.

How much Choline is Alpha GPC? And, how does it compare?

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Our Alpha GPC 99% encapsulation is 40% Choline by weight.Most Alpha GPC products use a 50% Alpha GPC which is ½ bulking agent ½ Alpha GPC. They only contain 20% choline
CDP choline is 18.5% choline
Citicholine is 18.5% choline

Why does it include magnesium stearate & B12 ?

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All of our products are vegan. For people that follow a vegan diet, they are at a higher risk of choline deficiency [1] and this is often a coupled with B12 deficiency. Vegans must supplement with B12 in order to obtain the recommended daily intake. Magnesium stearate is a flow agent and it is vital to ensure that each capsule contains 500mg of Alpha GPC

Could I be choline deficient?

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In 2014 the US National Centers for Disease Control and Prevention claimed that 90% of Americans are not getting enough choline in their diet. US Adequate Intake levels for men are 550mg/day and for women 425mg/day. In the EU it’s 480mg/day for pregnant women and 520mg/day for lactating women.

Long term - what should I notice?

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Double-blind placebo-controlled studies into patients with mild to moderate Alzheimer’s Dementia showed Alpha GPC was able to improve cognitive symptoms as assessed by 4 different rating scales for cognition. [15]

Are there any other benefits of choline?

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Yes; choline contributes to the maintenance of normal liver function, normal homocysteine metabolism and lipid metabolism. However, the evidence for strength and conditioning training and improvements in sports performance is too limited.

How long does Alpha GPC take to work ?

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When orally ingested it shows a relative spike in acetylcholine 1-3 hours post-ingestion. [3]

Is Alpha GPC safe ? How long can I take it for ?

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A double-blind placebo-controlled study into Alpha GPC tested 180 days of continuous supplementation without adverse effects. [16]

Are there any side effects of Alpha GPC ?

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Alpha GPC is safe when taken at the recommended dose. It is not recommended to exceed the stated dose. At higher than recommended doses a small number of people may experience side effects such as headaches or dizziness.

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