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Cognizance bundle

Regular price £44.99 Sale price £49.99
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Maintain your optimal brain with brain feed's cognizance bundle. 

What does the bundle contain ? 

  • 1 x plant based omega 3 DHA (30 pack)
  • 1 x Alpha GPC choline   (30 pack)

Choline and omega 3 DHA have a synergistic relationship that enhances cognitive development[1,2,3,4,5].

Omega 3 DHA contributes to the maintenance of normal brain function in adults and children [6].Our double concentrated DHA supplement is derived from algae and provides 500mg DHA in a single vegan omega 3 capsule.  In healthy young adults whose diets were low in DHA, supplementation improved memory [7]. In 30-54 year olds, omega 3 improved executive function in participants with low DHA levels [8].

Alpha GPC  is a potent form of the nutrient choline because it can cross the blood-brain barrier. Alpha GPC benefits cognitive function as It is the immediate precursor to the brain's memory & learning chemical acetylcholine which is released when conducting cognitive tasks. brain feed's is the world’s 1st 500mg Alpha GPC capsule containing 99% Alpha GPC*. The purest form of Alpha GPC. UK manufactured.
 

ingredients

Omega 3 DHA : algal oil (schizochytrium sp), antioxidant (mixed tocopherols) capsule [ starch, humectant (glycerol) & purified water]

Alpha GPC : Alpha GPC (99%), mannitol, vegetable cellulose capsule (HPMC), silicon dioxide, Magnesium stearate, vitamin B12

studies

[1] Ramanujan, K. (2022). Choline makes key nutrient available for baby development. Cornell Chronicle. https://news.cornell.edu/stories/2022/05/choline-makes-key-nutrient-available-baby-development#:~:text=The%20findings%20show%20that%20choline,the%20tissues%2C%20including%20the%20placenta

[2] Bortz, J. (2021). Is There a Relationship Between Choline and DHA? xeragenx. https://www.xeragenx.com/article/is-there-a-relationship-between-choline-and-dha

[3] McFadden, J. W. (2018). The Synergy of Choline and Omega-3 Fatty Acids for Optimized Transition Cow Nutrition: A Hypothesis. 2018 Cornell Nutrition Conference for Feed Manufacturers, 62–79.

[4] Ly, R., MacIntyre, B. C., Philips, S. M., McGlory, C., Mutch, D. M., & Britz-McKibbin, P. (2023). Lipidomic Studies Reveal Specific Circulating Phosphatidylcholines as Surrogate Biomarkers of Omega-3 Index. Journal of Lipid Research, 100445.

[5] Li, J., Jian, Y., Liu, R., Zhao, X., Mao, J., Wei, W., Jiang, C., Zhang, L., Wang, Y., & Zhou, P. (2023). Choline and Fish Oil Can Improve Memory of Mice through Increasing Brain DHA Level. Foods, 12(9), 1799.

[6] European Food Safety Authority - DHA and improvement of memory function: 2016 Article 13(5) of Regulation (EC) No 1924/2006 EFSA Journal, 14(5)

[7] Stonehouse et al - DHA supplementation improved both memory and reaction time in healthy young adults: a randomized controlled trial - American Journal of Clinical Nutrition

[8] Leckie et al - The effects of omega-3 fatty acids on neuropsychological functioning and brain morphology in mid-life adults: a randomized clinical trial - Psychological Medicine volume 50 issue 14 October 2019

[9] Murphy et al (2021). Long-chain omega-3 fatty acid serum concentrations across life stages in the USA: An analysis of NHANES 2011–2012. BMJ Open, 11(5), e043301.

[10] Derbyshire et al - Oily Fish and Omega-3s Across the Life Stages: A Focus on Intakes and Future Directions. 2019 Frontiers in Nutrition, 6, 165

[11] Dagai et al DHA Significantly Stimulates Immediate Early Response Genes and Neurite Outgrowth 2009 Neurochemical Research 34(5), 867–875.

[12] Schettini G, et al Molecular mechanisms mediating the effects of L-alpha-glycerylphosphorylcholine, a new cognition-enhancing drug, on behavioral and biochemical parameters in young and aged rats. Pharmacol Biochem Behav 1992 Sep;43(1):139-51.

FAQ's

How/when do I take them? + -

Take 1 omega 3 DHA capsule per day with water.

Take 1 Alpha GPC capsule per day with food. Ideally in the morning , at lunch or before starting work.

Are there any side effects? + -

There are no reported side effects for Algal Omega 3 containing 500mg DHA. Alpha GPC is safe when taken at the recommended dose. It is not recommended to exceed the stated dose. At higher than recommended doses a small number of people may experience side effects such as headaches or dizziness.

Could i be deficient in omega 3 or choline? + -

The UK & US have very low levels of DHA due to the western diet [9]. 68% of U.S. adults & 95% of children, do not consume enough Omega 3 in their diet to meet U.S. Dietary Guidelines [9]. Only 25% [10] of the UK population consume oily fish. The recommendation is 2 portions of fish per week [at least one should be oily]

In 2014 the US National Centers for Disease Control and Prevention claimed that 90% of Americans are not getting enough choline in their diet. US Adequate Intake levels for men are 550mg/day and for women 425mg/day. In the EU it’s 480mg/day for pregnant women and 520mg/day for lactating women.

Is it safe to take Omega 3 DHA with Alpha GPC ? + -

You can use Omega 3 DHA and Alpha GPC together. They work on different chemical pathways and they do not contraindicate. There may be a synergistic benefit of taking them in combination however, the synergistic benefit at these specific mg dosages hasn't been studied in clinical trial.

How long does it take to have an effect? + -

High-dose supplementation of DHA has been shown to begin increasing DHA levels after a month and maintain the levels throughout the supplementation period[11]. When orally ingested Alpha GPC it shows a relative spike in acetylcholine 1-3 hours post-ingestion. [12]

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