Skip to content
Close (esc)

SAVE 15% ON YOUR FIRST ORDER !

Use code NEW15 to save 15% on your 1st order. FREE UK next day delivery if you order before 3PM . FREE USA delivery 5-7 days.

5-htp, Griffonia, Griffonia simplicifolia

Do you know where 5-HTP comes from? – The Griffonia seed

Published Feb 11, 2016 | Updated Feb 9, 2024
article
filter

Despite its very synthetic sounding name, our 5-htp is a natural extract from the Griffonia simplicifolia seed and none of it is biosynthesised.

Where is the Griffonia simplicifolia seed from?

The Griffonia simplicifolia plant is grown in the tropical climate of Ghana, the Ivory Coast and Togo. It can grow up to 3m and when it flowers it produces seeds which, when ripe, contain between 14%-20% 5-htp. We only extract 5-htp from the seeds but the leaves of the plant actually contain serotonin in concentrations of 0.1-0.2%. They also have a surprisingly high protein content and contain calcium and phosphorous [1]. Its leaves are recognised as a natural anti-septic [2] and, in more traditional African medicine, chewing the stem is said to have an aphrodisiac effect whilst the plant's juices are used to treat urinary tract diseases.

5-HTP extraction

After industrial extraction methods have been applied to the seeds a 95–98% 5-HTP extract is obtained. (brain feed’s Griffonia seed extract of 102.5mg, standardised to 98% to provide 100mg 5-htp is the highest extract quality available.) Typically, most 5-HTP dietary supplements contain 25–100 mg of 5-HTP.

In this form the Griffonia seed extract is compressed into a tablet or mixed into a capsule as used as a dietary supplement for aiding depression treatment, appetite reduction and sleep induction. Studies in healthy volunteers found that oral administration of 5-HTP reduced the incidence of induced panic and associated symptoms when compared with placebo. [3]

Efficacy & benefits

Once ingested 5-HTP easily crosses blood-brain-barrier and is converted to serotonin. During the absorption of 5-HTP there is no need for special transport molecule. The absorption is also not influenced by amino acids, which allows 5-HTP to be administered with or without meals, without losing its efficacy.

This compound is well absorbed after oral administration (70% of the dose is introduced to bloodstream). It was proven, that therapeutic administration of 5-HTP may be efficient in depression, fibromyalgia, chronic head pains and insomnia [4, 5].

References

1. Bosch, CH, Griffonia simplicifolia (Vahl ex DC.) Baill. In: Schmelzer GH, Gurib-Fakim A, eds. Medicinal plants/Plantes médicinales 1 [CD-ROM]. Prota 11(1). Wageningen, Netherlands: PROTA; 2008.
2. Lemaire PA, Adosraku RK. An HPLC method for the direct assay of the serotonin precursor, 5-hydroxytrophan, in seeds of Griffonia simplicifolia . Phytochem Anal . 2002;13(6):333-337.
3. Maron E, Toru I, Vasar V, Shlik J. The effect of 5-hydroxytryptophan on cholecystokinin-4-induced panic attacks in healthy volunteers. J Psychopharmacol . 2004;18(2):194-199.
4. Keszthelyi D, Troost FJ, Masclee AM. Understanding the role of tryptophan and serotonin metabolism in gastrointestinal function. Neurogastroenterol. Motil. 2009; 21: 1239–1249.
5. Birdsall TC. 5-Hydroxytryptophan: A clinically-effective serotonin precursor. Altern. Med. Rev. 1998; 3: 271–280.

Leave a comment

Open tab

Please note, comments must be approved before they are published

Related articles

5HTP for sleep 5HTP vs melatonin serotonin and sleep serotonin and melatonin serotonin sleep serotonin vs melatonin nutrition and sleep natural supplements for sleep diet and sleep

Jun 18, 2024

Diet and sleep: New study explores nutrition's role in quality sleep

A new study confirms that 5-htp is the building block to your sleep hormone melatonin. Discover what are the effects of melatonin on sleep quality in older adults.
what is serotonin benefits serotonin sleep serotonin mood

May 3, 2024

What is serotonin? Your mood and sleep chemical explained

Wondering what serotonin is and how it can help boost your mood? Here's the ultimate guide to your feel-good chemical: from history and sources to supplementation and its benefits.
5htp benefits 5htp review 5htp dosage 5htp supplements

Mar 27, 2024

5-htp benefits & side effects: The truth behind feeling good

Wondering what 5-htp is and how it can help you feel better? Here's the ultimate guide to 5-htp: sources, supplementation, benefits & safety.
how to be a morning person  how to become a morning person  can we use in title please  how to wake up easier how to get out of bed when it's cold types of chronotypes                             sleep chronotypes

Oct 26, 2023

How to become a morning person? 3 secrets to join the 5AM club

How to be a morning person & how to wake up easier when its cold? Learn about types of chronotypes & ways to work with your type.
why mood changes during your period mood cycle what to eat on your period and mental health

Oct 23, 2023

Understanding you period mood cycle: How to eat right and feel bright on your periods

Period hormones can affect mental health. Find why mood changes during period & what to eat on your period to feel better.
how to deal with seasonal depression when does seasonal depression start ? what are the symptoms of sad  beat the winter blues  winter and mental health  mood affected by weather

Oct 20, 2023

How to deal with seasonal depression: 4 strategies to change your mood affected by weather

Feel like your mood changes as the seasons change? Read about SAD, seasonal affective disorder or seasonal depression, and discover how to manage it effectively with 4 tools.

Search

Shopping Cart